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Accelerated courses continue to be part of the changing academic landscape at Canadian universities. However, there is limited evidence to support their efficacy in relation to knowledge retention. A greater understanding of knowledge retention associated with accelerated courses (i.e., intensive full-day course for a one- or two-week duration) as compared to traditional courses (i.e., one three-hour lecture once a week for 12 weeks) will provide university stakeholders and administrators with evidence to determine whether quicker courses should be pursued in the postsecondary education environment. A longitudinal cohort design was developed with the objective of addressing the following research question: Does a difference in knowledge retention over time exist between students enrolled in traditional versus accelerated undergraduate courses?