Yukon, Nunavut and the Northwest Territories, Canada’s three Northern territories, are characterised as the most northerly permanently inhabited regions in the world, and the least populous regions of Canada. It is not yet clear, what if any gender-related issues stymie the growth of female-owned Northern Canadian enterprises. This study presents a perspective on the contexts of, and challenges facing, female entrepreneurs in Northern Canada. To inform this work, the study draws on previous research, analyses of survey data, and interviews with 11 key informants conversant with entrepreneurship in Northern Canada. Findings are used to advance questions for future research about women’s Indigenous (in the Canadian context, Aboriginal) and non-Indigenous (non-Aboriginal) entrepreneurship in Northern Canada.