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This article discusses issues affecting the advancement opportunities of persons with disabilities and strategies for overcoming barriers to advancement. Specifically, two major sources of treatment discrimination are identified: (1) individual factors (i.e., nature of the disability, stereotypes and stigma, multiple stigma and self-limiting behaviors) and (2) organizational factors (i.e., token status, outgroup status, perceptions of limited job-fit, lack of role models, lack of mentors, and lack of critical feedback). Strategies for overcoming these barriers and implications for human resource managers are discussed and include: diversity training, training for persons with disabilities, dealing with coworker resentment, accommodations, supervisor training, and mentoring/sponsorship programs. Implications for research on issues related to the advancement of persons with disabilities are also addressed.